Hunter researchers have helped unearth more than 100 genetic variants associated with schizophrenia after taking part in the largest study of the disease ever conducted.
The results - published in a world-leading publication - offer significant insights into susceptibility factors and provide promising therapeutic targets.
Professor Rodney Scott, Associate Professor Carmel Loughland, Professor Ulli Schall, Emeritus Professor Patricia Michie and Associate Professor Frans Henskens were part of the Psychiatric Genomics Consortium - comprising more than 80 institutions - that coordinated the investigation.
Data from the Newcastle-run Australian Schizophrenia Research Bank was pooled into a sample of 150,000 people including 37,000 diagnosed with schizophrenia.
Professor Scott said family history studies had indicated a genetic component but researchers now had leads to follow rather than 'scrambling about in the dark'.