Groups opposed to the changes - who have real fears for public safety, are determined to fight back in a bid to have it overturned.

Their hopes are pinned on Greens Senator Janet Rice who will move a disallowance motion on November 13. That will come five weeks after the amendment becomes law.

Senator Rice was supposed to put forward the motion on September 17, but the sudden death of her wife prompted it to be put back.

Rice will need the Labor Party's support to overturn the amendment and at the moment they are on the government's side.

Friends of the Earth Australia and Gene Ethics are two of the group who have joined with Slow Food Hunter Valley to try to educate farmers and shoppers about the changes.

Slow Food's Earth Market Maitland chairwoman Amorelle Dempster said removing the checks and balances on GMOs was a bad move, especially with the SDN1 type - called Site Directed Nucleases 1, which was invented in 2012.

She said GM foods will end up on the family dinner table and the people eating it will be oblivious.

She said the long-term impact on human health was one of her biggest concerns, along with the affect on the farming sector - especially small-scale farmers.

"There hasn't been enough research done, rigorous testing hasn't been done to know the impact on human health. Consumers have repeatedly said in all surveys that they don't want to eat genetically modified food," she said.