Augsburg shocked Borussia Dortmund 2-0 on Saturday to go top of the Bundesliga with a 100-per-cent record while Schalke coach David Wagner is under huge pressure after a 3-1 loss at home to Werder Bremen.
Daniel Caligiuri made the difference for Augsburg by providing Felix Uduokhai's first-half opener and adding the second himself shortly after the break.
Augsburg built on their opening win last week and top the pile until at least Sunday, when champions Bayern Munich visit Hoffenheim with both on three points.
A hat-trick from Bremen's Niclas Fuellkrug extended bottom club Schalke's record winless streak to 18 games and Wagner is set to come under scrutiny despite Mark Uth's late consolation.
Bayer Leverkusen and RB Leipzig shared the spoils in a 1-1 draw, Borussia Moenchengladbach were held 1-1 at home by Union Berlin, promoted VfB Stuttgart took a first win 4-1 at Mainz and Arminia Bielefeld did likewise, 1-0 over Cologne.
Dortmund started with Jude Bellingham, Jadon Sancho, Giovanni Reyna and Erling Haaland all born in or after the year 2000 but their youthful attack was repelled.
Caligiuri's delightful free-kick gave defender Uduokhai a simple header in the 40th minute and nine minutes into the second half the provider turned scorer by finishing Florian Niederlechner's superb pass.
Norwegian Haaland was returning to the scene of his January debut for Dortmund, where he hit a hat-trick off the bench in a 5-3 comeback win, but this time there was no turnaround.
Augsburg are the only side so far with two wins to top the table from Frankfurt, who lead Leipzig and Bielefeld on goal difference, on four points.
Schalke are bottom with two losses, just one goal scored and a goal difference of minus-10 after another horror show against Bremen following their 8-0 opening loss in Munich.
Schalke were miserable and could be grateful their fans were shut out of the stadium due to the high local infection rate for the coronavirus.
Uth scored with the last kick of the ball but they slumped to what Opta said was the worst-ever Bundesliga start after two rounds.
Emil Forsberg opened the scoring for Leipzig in Leverkusen but Kerem Demirbay equalized in a match the hosts could have won when teenager Florian Wirtz hit the post and former Leipzig loanee Patrik Schick had a goal ruled out for offside.
Marcus Thuram returned from injury to head Gladbach in front over Union but a looping reply from Nico Schlotterbeck rescued a late draw for Union.
Both sides lost on the opening day but Union will be happier with the draw on this occasion.
Mainz had a difficult week with a brief player strike after Adam Szalai was removed from the first-team squad but Robin Quaison gave them a 13th-minute lead at home to Stuttgart.
Silas Wamangituka, Daniel Didavi, Mateo Klimowicz and Sasa Kalajdzic turned the contest, however, to give the promoted visitors a first win back in the top-flight and leave the hosts without a point after Moussa Niakhate was sent off.
Fellow newcomers Bielefeld also triumphed, with Joan Simun Edmundsson's late goal against pointless Cologne giving them a first Bundesliga win since March 2009.
Australian Associated Press