Harry Johnson-Holmes reckons "why not" and Nic White feels like "there's no reason games can't come up here".
The homegrown Wallabies pair both endorse more rugby union Tests being played in the region in the future, a view shared by Venues NSW and City of Newcastle.
It comes ahead of Saturday's encounter between Australia and Argentina at McDonald Jones Stadium as part of this year's rescheduled Tri Nations tournament.
This fixture, originally set as a double header before South Africa withdrew from the 2020 competition, will be followed by the Pumas staying on to meet New Zealand at the same venue on November 28.
Wallabies halfback White was in the stands the last, and only other, time a Test was played in Newcastle eight years ago and supports another return down the track.
"I hope there are Tests come this way," White told the Newcastle Herald.
"If there's a good crowd there [on Saturday] ... we're [already] getting more and more support up here so there's no reason games can't come up here."
Johnson-Holmes, also with the Wallabies in camp in the Hunter, has represented the NSW Waratahs in Super Rugby clashes played at the Turton Road facility during the previous two seasons.
"We've got the fans, we've got the beautiful landscape, we've got the world-class stadium, so why not?" the prop said.
"From the Waratahs the feedback has always been great and from an international level it's always going to attract attention.
"So for Newcastle to get that recognition and push that case and get that opportunity, it's the kind of thing where it should only lead to more opportunities."
Acting minister for sport Geoff Lee said Venues NSW were keen to attract "premium content" for the state, "in particular regional communities".
"Newcastle loves its rugby and we share their ambition to make McDonald Jones Stadium another Wallabies fortress," Lee said.
Lord Mayor Nuatali Nelmes said City of Newcastle were "proud" to host these upcoming matches and "we continue to work with Venues NSW and major stakeholders to attract and secure high-profile, international sporting events".
Former national captain Phil Kearns recently said that McDonald Jones Staium would likely be part of Australia's bid for the 2027 World Cup.
Recently re-signed Knights rugby league playmaker Blake Green met with Johnson-Holmes and White at Merewether on Wednesday and said "it's great for Newcastle to have some international rugby".
Limited tickets were still available online but the crowd has been capped at around 12,000 because of COVID-19 restrictions.
Meanwhile, local club The Waratahs will host a coaching clinic at Waratah Oval on Thursday with assistance from Rugby NSW and the Hunter Wildfires.
Waratah's Corpus Christi, Mayfield West, Plattsburg and Minmi will be some of the primary schools participating with the Dave Bowtell Trophy and Ray Frost Memorial competitions to run at the same venue early next year.