Australian Red Cross Lifeblood needs 121 Australians to donate blood and plasma in the lead up to Australia Day in Maitland.

Lifeblood spokesperson Brian Bruce said fewer people tend to donate on public holidays and Australia Day is no exception.

"We know that many of our regular donors will be taking a well-earned break, and others may decide to take Monday off as well, giving themselves a four day weekend," he said.

"But the need for blood never stops. This Australia Day there will be people in hospital needing blood for cancer treatment, trauma, surgery, bleeding disorders and obstetrics. It's vital that Australians step up to ensure patients receive the blood they need."

The most pressing dates are from Friday, January 22 until the public holiday on Tuesday, January 26, when Lifeblood Donor Centres will be open.

"There is nothing more Australian than helping out a mate, and if you're able to help save the life of a complete stranger, that makes you a bloody legend," Mr Bruce added.

With one in three Australians needing blood or blood products in their lifetime, but only one in 30 donating, Lifeblood is encouraging people who have never given blood to roll up their sleeves.

"Donating blood is simple. It only takes an hour of your time and you are helping to save the lives of three fellow Australians," Mr Bruce said.

"What better way to kick off the year and give back to your community?"

To give blood, visit lifeblood.com.au, call 13 14 95 or download the free Donate Blood app.