NSW Health has confirmed a mass vaccination centre in Newcastle is being "progressed" to serve the city's large population and the people of the surrounding regions.

State Health Minister Brad Hazzard said Hunter health officials had been scouting for potential sites in or near Newcastle following the success of the vaccine hub at Sydney's Olympic Park.

They are looking for a vacant commercial premises of at least 2000 square metres with access to a "great amount" of parking.

The planned vaccination centre is expected to work in the same way as the Sydney hub, which operates from a two-storey office building at Olympic Park.

Minister Hazzard told ABC Newcastle he hoped the hub would have the capacity to administer a "couple of thousand" of Pfizer and AstraZeneca vaccines each day - "possibly more".

They hoped to have the Hunter vaccine hub operational "as soon as possible".

A NSW Health spokesperson said they would provide further updates "when available".

Hunter GP Association spokeswoman Dr Fiona Van Leeuwen said they had been agitating for a Newcastle vaccination hub.

"It just makes sense," Dr Van Leeuwen said.

"We have the population to support it, and to assist the rollout significantly.

"It will help expedite vaccination numbers, especially to high risk groups that currently have low coverage, like people with disabilities.

"A mass vaccination hub would be convenient, it would be fast, it would be efficient, and it would be low cost.

"It would also help support and preserve the general practice workforce to provide core, essential services."

Dr Van Leeuwen said there was a "significant amount" of vaccine hesitancy within the community.

Many Hunter doctors had "excess capacity" of the AstraZeneca vaccine at present due to patients choosing to wait to see if the recommendations changed again.

"We need more appropriate, supportive information for everybody to work out the risk-benefit ratio of not having the COVID vaccine compared with the risks of the low incidence side effects and also getting COVID at a certain age as well," she said.

"I have had the AstraZeneca vaccine. GPs were not in the 1a phase of the rollout - we weren't considered frontline health workers - so most GPs have only been eligible for AstraZeneca."

A Newcastle Herald poll found 86.5 per cent of 89 respondents would get the vaccine if Newcastle opened a mass hub. Almost 8 per cent were "undecided", and almost 6 per cent said they wouldn't.

"I don't think we are seeing the trauma of what is happening overseas here," Dr Van Leeuwen said. "It is easy to be shielded, or sheltered, from the devastation of the Coronavirus in other parts of the world.

"But the likelihood of Coronavirus coming back into the community and spreading is an inevitability, I think."

NSW Health said it had administered its highest number of COVID-19 vaccines in one day, with a record 11,720 vaccines administered in the 24 hours to 8pm Tuesday.

People aged 50 to 69 became eligible to receive the AstraZeneca vaccine at GP clinics this week.

People aged 40 to 49 can register their interest in receiving the Pfizer shot at a NSW Health vaccination clinic through Service NSW.