On Tuesday crime statistics revealed a 59 per cent increase of amphetamine use and possession in the Hunter over two years.

Now NSW Police has launched an advertising campaign which calls on residents to contact Crime Stoppers with any information that could help to shut down drug supply syndicates and laboratories.

"Please do not underestimate the immensely positive impact one anonymous call to Crime Stoppers can make," NSW Police Commissioner Andrew Scipione said.

"In September 2012 a single anonymous call to Crime Stoppers led to the seizure of 585 kilograms of ice.

"Make no mistake about it: this call stopped millions of deals from making it to the street, preventing untold harm, and no doubt saving countless lives.

"As the advertisements make patently clear, if you see something you're concerned about, please let us know.

"Your information could help us smash apart an ice supply syndicate and directly prevent many thousands of lives from being destroyed by drugs."

Central Hunter crime manager Detective Inspector John Zdrilic called for more tip-offs from Maitland residents back in March, after an alarming rise in the number of drug laboratories in the Hunter region.

The call for the police and community to work together has been renewed, as ice or crystal methamphetamine continues to have a devastating impact on families and communities across regional NSW.

"There are two main problems with the drug ice," Inspector Zdrilic said.

"One, the highly addictive nature of the drug and two, the violent or psychotic effect it can have on people.

"It is sporadic, one minute the person can be normal and then it escalates.

"They become a risk to other people and themselves."

Inspector Zdrilic said small things such as glassware or a strange smell could be enough for police to investigate a site.

Ice laboratories can be volatile and are often run by untrained people working with dangerous chemicals, making it paramount to report anything out of the ordinary.

Crime Stoppers NSW CEO Peter Price reassured the public that information would be treated in the strictest confidence.

"One anonymous call to Crime Stoppers can make a huge difference to thousands of lives," Mr Price said.

"We don't need to know your name, we don't need to know where you are calling from, all we need is the information you have to hand.

"We can pass this information on to investigators and they can use it in their efforts to combat drug crime.

"It may just be the missing link they need to crack open a complex case."

Police are urging anyone with information in relation to drug crime to call Crime Stoppers on 1800 333 000 or use the Crime Stoppers online reporting page nsw.crimestoppers.com.au.